2-Methoxyestradiol loaded mesoporous polydopamine nanoprobes for hypoxia alleviation and sorafenib synergistic treatment of hepatocellular carcinoma

作者：Wang, Peifeng; Du, Yang; Zhao, Xingyang; Hu, Yueyang; Zhou, Tianjun; Liang, Xiaolong^*; Fang, Chihua^*; Tian, Jie^*

来源：MATERIALS & DESIGN, 2023, 232: 112137.

DOI：10.1016/j.matdes.2023.112137

• Hepatocellular carcinoma
• Mesoporous polydopamine
• Photothermal therapy
• Sorafenib
• Hypoxia

Hepatocellular carcinoma is a common and highly malignant disease. As a currently designated systemic chemotherapeutic agent for advanced Hepatocellular carcinoma, sorafenib has been confronted with dilemma of drug-resistance caused by tumor hypoxia, which hinders the therapeutic efficacy of the drug. Based on this, amultifunctional mesoporous polydopamine nanoprobe 2Me-SPIO-CY5.5@AAZ-MPDA with a mesoporous frame loaded 2-Methoxyestradiol, Superparamagnetic Iron Oxide Nanoparticles and the near-infrared dye cyanine 5.5, conjugated with hypoxia Hepatocellular carcinoma-specific targeting molecule of sulfonamides acetazolamide, is fabricated for hypoxic region targeting, sorafenib resistance reversion and photothermal therapy of Hepatocellular carcinoma. In addition, the magnetic resonance imaging/fluorescence/photoacoustic tri-modal imaging ability enables the tracing of the nanoprobes and monitoring the treatment procedure in vivo, providing a new methods of imaging-guided Hepatocellular carcinoma synergic treatment which improves the long-term therapeutic effects of sorafenib.

• 单位
  北京大学; 南方医科大学; 北京航空航天大学; 中国科学院; 广东省人民医院; 中国科学院研究生院