One-Pot Synthesis of Diaryl 1,2-Diketones via Zn-Mediated Reductive Coupling

作者:Yu, Zhi-Cheng; Zhou, You; Chen, Xiang-Long; Ma, Jin-Tian; Wang, Li-Sheng; Wu, Yan-Dong; Wu, An-Xin*
来源:Journal of Organic Chemistry, 2022.
DOI:10.1021/acs.joc.2c01658

摘要

A reductive coupling reaction was established for the synthesis of diaryl 1,2-dicarbonyl compounds from aryl methyl ketones in good yields. The mechanistic study showed the reaction undergoes C(CO)-C(sp3) bond cleavage, with the reductive coupling reaction occurring through an electron transfer process. Notably, the reaction not only is simple to operate but also has mild reaction conditions and a wide range of applicable substrates.