A cancer cell membrane coated, doxorubicin and microRNA co-encapsulated nanoplatform for colorectal cancer theranostics

作者：Zhu, Sihao; Li, Ziyuan; Zheng, Dongye; Yu, Yue; Xiang, Jing; Ma, Xiao; Xu, Dongqing; Qiu, Jiajun; Yang, Ziyu; Wang, Zhiyi; Li, Jun; Sun, Hongfang; Chen, Weiqiang; Meng, Xiangxi^*; Lu, Yanye^*; Ren, Qiushi^*

来源：Molecular Therapy-Oncolytics, 2023, 28: 182-196.

DOI：10.1016/j.omto.2022.12.002

• POLYMER NANOPARTICLES
• ANTIANGIOGENIC THERAPY
• TUMOR-GROWTH
• DELIVERY
• ANGIOGENESIS
• VEGF
• SELF
• PH
• HYPOXIA
• DISEASE

Endogenous microRNAs (miRNA) in tumors are currently under exhaustive investigation as potential therapeutic agents for and untargeted delivery, limited biological effect, and currently unclear side effects remain unsettled issues that frustrate clinical application. To address this, a versatile targeted delivery system for multiple therapeutic and diagnostic agents should be adapted for miRNA. In this study, we developed membrane-coated sulating doxorubicin (Dox) and miRNA-190-Cy7. Such a system showed low biotoxicity, high loading efficiency, and superior targeting ability. Systematic delivery of m-PPDCNPs in mouse models showed exceptionally specific tumor accumulation. Sustained release of miR-190 inhibited tumor angiogenesis, tumor growth, and migration by regulating a large group of angiogenic effectors. Moreover, m-PPDCNPs also enhanced the sensitivity lines and mouse models. Together, our results demonstrate a stimulating and promising m-PPDCNPs nanoplatform for colorectal cancer theranostics.

• 单位
  北京大学; 中国科学院; 河北医科大学; 上海交通大学