The sources of salidroside and its targeting for multiple chronic diseases

摘要

Salidroside, a phenolic compound widely existing in tubers of Rhodiola plants, has been found to have many important biological activities recently. This review summarizes the chemical synthesis and biosynthesis methods of salidroside, and introduces its pharmacological effects on diseases of liver, kidney, nervous and cardiovascular systems. A significant of studies have shown that salidroside has treatment effects on neurological diseases such as hypoxic-ischemic brain and degenerative diseases. It can prevent cardiovascular diseases by protecting cardiomyocytes and vascular endothelial cells. Salidroside can inhibit the release of oxidative stress and inflammatory factors, hence exerting protective function on liver and kidney. In addition, salidroside displays an anti-inflammatory effect by regulating the signaling pathways of NF-kappa B, JAK2-STAT3 and AMPK-SirT1. It can also promote cancer cell apoptosis and inhibit cancer cell proliferation. In conclusion, although the multiple bioactivities of salidroside are conformed, the clinical data are insufficient and needs to be concerned in the future.

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