Effects of neuronal morphology and time delay on inverse stochastic resonance in two-compartment neuron model

作者：Liu, Chaoyue; Yu, Dong; Li, Tianyu; Wang, Xueqin; Xie, Ying; Jia, Ya^*

来源：Physics Letters, Section A: General, Atomic and Solid State Physics , 2024, 493: 129268.

DOI：10.1016/j.physleta.2023.129268

• Two-compartment neuron
• Chemical autapse
• Gaussian white noise
• Inverse stochastic resonance

Inverse stochastic resonance (ISR) is a depression phenomenon of firing activity of neuron with respect to noise, and the characteristics of neural systems are determined by neuronal morphology. The effects of neuronal morphology on ISR remain unknown. Here, ISR effect in two-compartment neuron model is investigated. It is found that the neuronal morphology influences the number of stable states of neuronal discharge, thereby governs ISR effect. The ISR effect appears within the parameters region of bistable state, which is consistent with prior experimental and theoretical findings. With the increasing of time delay, average firing rate of neuron exhibits multiple local minima, which is known as multiple ISR. Time delay and coupling strength affect neuronal firing pattern by altering phase of stimulus and strength of autaptic current. These results may provide a novel perspective on ISR effect in nervous system.

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