Advances in the Modifications of 4-Monosubstituted 1,2,3-Triazoles

摘要

1,2,3-Triazole is a kind of 5-membered N-heterocycle widely applied in pharmaceutical, pesticide and materials. 1,2,3-Trizole chemistry has stepped into a new era in the fields of organic synthesis and pharmacochemistry since the Cu-catalyzed azide-alkyne dipolar cycloaddition was founded by the Sharpless and Meldal groups in 2002. 4-Monosubstituted 1,2,3-triazole is a noble member in its family owing to the structural merits of facile modifications, leading to novel molecules. The transformations of 4-monosubstituted 1,2,3-triazoles basing on different reaction sites including the N-1, N-2 and N-3 are reviewed. The substrate scope, limitation, and representative mechanism are also discussed.

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