Advances in the Modifications of 4-Monosubstituted 1,2,3-Triazoles

作者：Yang Baomin; Zhang Shuitao; Dong Xian; Qin Guiping^*; Jiang Yubo^*

来源：Acta Chimica Sinica, 2023, 81(11): 1577-1589.

DOI：10.6023/A23060284

• AZIDE-ALKYNE CYCLOADDITION
• AZA-MICHAEL ADDITION
• C-H AMINATION
• REGIOSELECTIVE SYNTHESIS
• EFFICIENT SYNTHESIS
• CLICK CHEMISTRY
• 4,5-DISUBSTITUTED 2H-1,2,3-TRIAZOLES
• 2,4-DISUBSTITUTED 1,2,3-TRIAZOLES
• FACILE SYNTHESIS
• TRIAZOLES

1,2,3-Triazole is a kind of 5-membered N-heterocycle widely applied in pharmaceutical, pesticide and materials. 1,2,3-Trizole chemistry has stepped into a new era in the fields of organic synthesis and pharmacochemistry since the Cu-catalyzed azide-alkyne dipolar cycloaddition was founded by the Sharpless and Meldal groups in 2002. 4-Monosubstituted 1,2,3-triazole is a noble member in its family owing to the structural merits of facile modifications, leading to novel molecules. The transformations of 4-monosubstituted 1,2,3-triazoles basing on different reaction sites including the N-1, N-2 and N-3 are reviewed. The substrate scope, limitation, and representative mechanism are also discussed.

• 单位
  云南大学