Roles and Molecular Mechanisms of Biomarkers in Hepatocellular Carcinoma with Microvascular Invasion: A Review

作者：Zhao, Xudong; Wang, Yudan; Xia, Haoming; Liu, Shuqiang; Huang, Ziyue; He, Risheng; Yu, Liang; Meng, Nanfeng; Wang, Hang; You, Junqi; Li, Jinglin; Yam, Judy Wai Ping^*; Xu, Yi^*; Cui, Yunfu^*

来源：Journal of Clinical and Translational Hepatology, 2023, 11(5): 1170-1183.

DOI：10.14218/JCTH.2022.00013S

• Hepatocellular carcinoma
• Microvascular invasion
• Biomarkers
• Progress
• Molecular mechanism

Hepatocellular carcinoma (HCC) being a leading cause of cancer-related death, has high associated mortality and recurrence rates. It has been of great necessity and urgency to find effective HCC diagnosis and treatment measures. Studies have shown that microvascular invasion (MVI) is an independent risk factor for poor prognosis after hepatectomy. The abnormal expression of biomacromolecules such as circRNAs, lncRNAs, STIP1, and PD-L1 in HCC patients is strongly correlated with MVI. Deregulation of several markers mentioned in this review affects the proliferation, invasion, metastasis, EMT, and anti-apoptotic processes of HCC cells through multiple complex mechanisms. Therefore, these biomarkers may have an important clinical role and serve as promising interventional targets for HCC. In this review, we provide a comprehensive overview on the functions and regulatory mechanisms of MVI-related biomarkers in HCC.

• 单位
  哈尔滨医科大学; 北京大学; y