A meta-analysis on the role of pre-existing chronic disease in the cardiac complications of SARS-CoV-2 infection

作者：Sinclair, Jane E.; Zhu, Yanshan; Xu, Gang; Ma, Wei; Shi, Haiyan; Ma, Kun-Long; Cao, Chun-Feng; Kong, Ling-Xi; Wan, Ke-Qiang; Liao, Juan; Wang, Hai-Qiang; Arentz, Matt; Redd, Meredith A.; Gallo, Linda A.; Short, Kirsty R.^*

来源：iScience, 2021, 24(4): 102264.

DOI：10.1016/j.isci.2021.102264

• COVID-19 PNEUMONIA
• MYOCARDIAL INJURY
• PREVALENCE
• MECHANISMS
• OUTCOMES
• H7N9

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been associated with multiple direct and indirect cardiovascular complications. We sought to analyze the association of host co-morbidities (chronic respiratory illnesses, cardiovascular disease [CVD], hypertension or diabetes mellitus [DM]) with the acute cardiovascular complications associated with SARS-CoV-2 infection. Individual analyses of the majority of studies found median age was higher by similar to 10 years in patients with cardiovascular complications. Pooled analyses showed development of SARS-CoV-2 cardiovascular complications was significantly increased in patients with chronic respiratory illness (odds ratio (OR): 1.67 [1.48, 1.88]), CVD (OR: 3.37 [2.57, 4.43]), hypertension (OR: 2.68 [2.11, 3.41]), DM (OR: 1.60 [1.31, 1.95]) and male sex ( OR: 1.31 [1.21, 1.42]), findings that were mostly conserved during sub-analysis of studies stratified into global geographic regions. Age, chronic respiratory illness, CVD, hypertension, DM, and male sex may represent prognostic factors for the development of cardiovascular complications in COVID-19 disease, highlighting the need for a multidisciplinary approach to chronic disease patient management.