Impact of the pulmonary ventilation function on the prognosis of suspected asthma patients: a retrospective observational study

作者：Zhou, Ming-juan^*; Fu, Li; Lin, Wen-qian; Wu, Zhen-ni; Nie, Fang; Ye, Chu-yin; Zhao, Wen-han

来源：JOURNAL OF ASTHMA, 2024.

DOI：10.1080/02770903.2024.2303771

• Bronchial provocation test
• suspicious positive result
• pulmonary ventilation function
• retrospective observational study
• asthma
• prognosis
• chronic respiratory disease
• spirometry
• forced expiratory volume
• forced vital capacity
• peak expiratory flow rate
• multivariable logistic regression analysis

ObjectiveAsthma is a common chronic respiratory diseases, and the relationship between pulmonary ventilation function and the prognosis of patients with suspected asthma is not well understood. This study aims to explore the impact of pulmonary ventilation functions on the prognosis of patients with suspected asthma.MethodsThis retrospective observational study included patients with suspected asthma who were diagnosed and treated at the Guangdong Provincial Hospital of Traditional Chinese Medicine between August 2015 and January 2020. The primary outcome of interest was improvement in asthma symptoms, as measured by bronchial provocation test (BPT) results within one year after diagnosis. The impact of pulmonary ventilation functions on prognosis was explored by multivariable logistic regression analysis.ResultsSeventy-two patients were included in the study. Patients with normal (OR = 0.123, p = .004) or generally normal (OR = 0.075, p = .039) pulmonary ventilation function were more likely to achieve improvement in asthma symptoms compared with patients with mild obstruction. There were no significant differences between the improvement and non-improvement groups in baseline characteristics.ConclusionThese results suggest that suspected asthma patients with normal or generally normal pulmonary ventilation function are more likely to achieve improvement in asthma symptoms within one year compared to patients with mild obstruction.

• 单位
  广州中医药大学; 广东省人民医院