(8S, 9R)-Dihydroisoflavipucine, a New Isoflavipucine Derivative from the Endophytic Fungi Botryosphaeria dothidea

作者：Chen, Hui; Li, Wendan; Xue, Lian; Liu, Xiuji; Zhou, Yiqing^*; Deng, Zhangshuang^*

来源：Records of Natural Products, 2023, 17(2): 358-362.

DOI：10.25135/rnp.360.2206.2500

• Dihydroisoflavipucine
• isoflavipucine
• Taxus mairei
• endophytic fungi
• Botryosphaeria dothidea
• antiproliferative activity

A new isoflavipucine derivative, (8S, 9R)- dihydroisoflavipucine (1), is isolated from an ethyl acetate extract of endophytic fungi Botryosphaeria dothidea (D4-2) derived from Taxus mairei. The structure of 1 is elucidated based on nuclear magnetic resonance, circular dichroism, and mass spectrometry. The antiproliferative activity of the isolates against breast cancer cells MDA-MB-231, MCF7 and 4T1 are evaluated.