The use of 5-aminolevulinic acid in resection of pediatric brain tumors: a critical review 20190327

作者：Zhang Chenran^*; Boop Frederick A; Ruge John

来源：Journal of Neuro-Oncology, 2019, 141(3): 567-573.

DOI：10.1007/s11060-018-03004-y

• 5-Aminolevulinic acid (5-ALA)
• Pediatric brain tumor
• Extent of resection

The compound, 5-aminolevulinic acid (5-ALA) is approved for fluorescence-guided resections of malignant gliomas in Europe and other countries for use in adults, but not for children. The application of 5-ALA in children remains an off-label use. Several case reports on fluorescence-guided surgery use in children have been published, yet no prospective study has been conducted. Here we systematically review the reported studies and discuss the usefulness, application, and safety of 5-ALA use in resection of pediatric brain tumors.

• 单位
  上海交通大学