Electrochemical Oxidative C(sp2)-H Amination of Aldehyde Hydrazones with Azoles

Authors：Fu, Zhi-Mei; Ye, Jian-Shan; Huang, Jing-Mei^*

Source：Organic Letters, 2022, 24(32): 5874-5878.

DOI：10.1021/acs.orglett.2c01782

• BIOLOGICAL-ACTIVITIES
• HETEROCYCLES
• CATALYSIS

A general and highly efficient method for the electrochemical C(sp(2))-H amination of aldehyde hydrazones with azoles has been developed. This reaction proceeds under exogenous metal-, catalyst-, and oxidant-free conditions to provide aminated hydrazone derivatives in good to excellent yields. This strategy applies to both aromatic and aliphatic aldehyde hydrazones and tolerates a broad range of functional groups.