State-of-Art Advances on Silylation-Initiated Annulation Reactions

Authors：Nan Ning; Wu Shuang; Qin Jinghao^*; Li Jinheng^*

Source：CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2023, 43(10): 3414-3453.

DOI：10.6023/cjoc202307025

• C-H functionalization
• organic silanes
• unsaturated bonds
• annulation reaction

Organosilicon compounds are important monomers and useful organic molecules in many materials, and are widely used synthetic intermediates in chemical synthesis. Therefore, people have been working hard to develop new methods to construct silicon containing chemical bond, especially C-Si bonds. Since Sakurai and Imai reported the first palladium catalyzed cycloaddition reaction of silcyclobutane with acetylene in 1975, transition metal catalyzed silyl annulation has been developed rapidly. With the rapid development of free radical reactions, researchers have expanded them to the annulation reaction between organic silicon molecules, ushering in new developments in the annulation reaction of silicon. The transition metal catalyzed silylative annualtion reaction, free radical initiated silylative annualtion reaction, and C+ ion initiated silylative annualtion reaction are mainly discussed. Finally, a summary of the current research progress is described.

• Institution
  南昌航空大学; 兰州大学