Evaluation of the therapeutic effect of mitomycin-loaded hydrogel in inhibiting tumor-cell proliferation and invasion in pancreatic cancer

Authors：Wang, Wen -Wen; Yang, Li-Jie; Guo, Jun-Feng^*

Source：Materials Express, 2023, 13(1): 81-84.

DOI：10.1166/mex.2023.2318

• Pancreatic Cancer
• Hydrogel
• Mitomycin
• Biocompatibility

Pancreatic cancer is a common tumor of the digestive system with a high degree of malignancy and poor prognosis. Its incidence has significantly increased worldwide in recent years. Currently, approximately 90% of patients cannot be treated surgically. Thus, drug therapy plays an important role in pancreatic cancer treatment. In this study, hydrogels loaded with mitomycin were prepared from hyaluronic acid and carboxymethyl chitosan, which have excellent biocompatibility. SEM results showed that the hydrogels had a IP: 203.8.109 20 On: Wed, 29 Mar 2023 13:47:11 three-dimensional interoperable porus structure, and CCK-8 results showed that hydrogels loaded with mitoCopyright: Am rican Scien ific Publishers mycin significantly reduced cancer-cell proliferaton. The hydrogels also reduced the migration of cancer cells Delive ed by Ingenta in a dose-dependent manner, indicating their potential use as a drug-carrier material for pancreatic cancer treatment.

• Institution
  哈尔滨医科大学; 1; 6