Endothelium-Mimetic Surface Modification Improves Antithrombogenicity and Enhances Patency of Vascular Grafts in Rats and Pigs

作者：Wei, Yongzhen; Jiang, Huan; Chai, Chao; Liu, Pei; Qian, Meng; Sun, Na; Gao, Man; Zu, Honglin; Yu, Yongquan; Ji, Guangbo; Zhang, Yating; Yang, Sen; He, Ju; Cheng, Jiansong^*; Tian, Jinwei; Zhao, Qiang^*

来源：JACC-Basic to Translational Science, 2023, 8(7): 843-861.

DOI：10.1016/j.jacbts.2022.12.009

• antithrombogenic surface modification
• endothelialization
• nitric oxide
• thrombomodulin
• vascular grafts

We first identified thrombomodulin (TM) and endothelial nitric oxide (NO) synthase as key factors for the antithrombogenic function of the endothelium in human atherosclerotic carotid arteries. Then, recombinant TM and an engineered galactosidase responsible for the conversion of an exogenous NO prodrug were immobilized on the surface of the vascular grafts. Surface modification by TM and NO cooperatively enhanced the antithrombogenicity and patency of vascular grafts. Importantly, we found that the combination of TM and NO also promoted endothelialization, whereas it reduced adverse intimal hyperplasia, which is critical for the maintenance of vascular homeostasis, as confirmed in rat and pig models. (c) 2023 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

• 单位
  哈尔滨医科大学; 南开大学