KIF4A: A potential biomarker for prediction and prognostic of prostate cancer

作者：Chen, Jiahong; Li, Maozhang; Fang, Shumin; Zhou, Xiaobo; Liao, Jinxian; Yang, Shengbang; Zhu, Jianguo; He, Renqiang; Lu, Jianming; Jiang, Funeng; Xu, Xiaoming; Zhong, Weide^*

来源：Clinical and Investigative Medicine, 2020, 43(3): E49-E59.

• CELL CARCINOMA
• EXPRESSION
• PROGRESSION
• PROMOTES

Purpose: To investigate the clinical relevance and biological function of the kinesin super-family protein 4A (KIF4A) expression in prostate cancer (PCa). @@@ Methods: We examined 1) the relationship between the expression of KIF4A and clinico-pathological characteristics of PCa patients using a tissue microarray and the Cancer Genome Atlas database, 2) the prognostic value of KIF4A expression in patients using Kaplan-Meier plots and 3) the functions of KIF4A in LNCaP and DU145 cells, such as cell proliferation, cell cycle and cell apoptosis. @@@ Results: Compared with normal prostate, the mRNA and protein expressions of KIF4A were up-regulated in PCa. The up-regulation expression rates of KIF4A in PCa were significantly related to the Gleason score (P<0.001). The elevated KIF4A level also predicted independently a poor biochemical recurrence-free and disease-free survival of PCa patients. The ectopic expression of KIF4A in PCa was significantly positively associated with the capability of migration and proliferation. @@@ Conclusion: Over-expression of KIF4A correlated with the aggressiveness of PCa and with biochemical recurrence-free survival. Thus, KIF4A is a potential diagnostic indicator and therapeutic target for PCa.

• 单位
  南方医科大学; 1; 中国科学院研究生院; 贵州大学