One-Pot Synthesis of Polysubstituted Pyrroles via Sequential Ketenimine Formation/Ag(I)-Catalyzed Alkyne Cycloisomerisation Starting from Ylide Adducts

摘要

Main observation and conclusion @@@ A simple one pot synthesis of polysubstituted pyrroles via ketenimine formation/Ag(I)-catalyzed alkyne cycloisomerisation has been developed. The easily accessible phosphorane ylide derivatives reacted with isocyanates, producing highly active ketenimines that were then treated with amines, which afforded substituted pyrroles by a 5-exo-dig cyclization/isomerization in the presence of a Ag(I) catalyst in good overall yields.

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