The prognostic value of adding systemic inflammation response index to Epstein-Barr virus DNA in childhood nasopharyngeal carcinoma: A real-world study

作者：Jin, Ya-Nan; Liu, Bao-Qiu; Peng, Kun-Wei; Ou, Xue-Qing; Zeng, Wu-Shuang; Zhang, Wang-Jian; Marks, Tia; Yao, Ji-Jin^*; Xia, Liang-Ping^*

来源：Head and Neck, 2022, 44(6): 1404-1413.

DOI：10.1002/hed.27033

• children and adolescents
• Epstein-Barr virus DNA
• nasopharyngeal carcinoma
• prognosis
• systemic inflammation response index

Background To assess the prognostic value of the systemic inflammation response index (SIRI) combined with plasma load of Epstein-Barr virus (EBV) DNA in children and adolescents with locoregionally advanced nasopharyngeal carcinoma (CALANPC). Methods A total of 205 consecutive patients with CALANPC were enrolled. We used recursive partitioning analysis (RPA) to classify patients into various risk groups, with a primary endpoint of overall survival (OS). Results Elevated SIRI (>= 1.53) and EBV DNA (>= 4000 copy/ml) were significantly associated with inferior OS in CALANPC. RPA categorized patients into low- and high-risk groups based on prognostic factors. Survival curves showed excellent discrimination in OS (95.3% vs 77.6%; p < 0.001) between the low- and high-risk groups. A significant improvement was confirmed using the prognostic methods for conventional TNM staging systems (p < 0.05). Conclusions The combination of SIRI with EBV DNA provided a more detailed understanding of patient risks, and enhanced risk discrimination in CALANPC.

• 单位
  5; 1; 广东药学院; 中山大学