Gadolinium(III) Porphyrinoid Phototheranostics

作者：Jin, Guo-Qing; Lai, Haoqiang; Yang, Zi-Shu; Ning, Yingying; Duan, Linqi; Zhang, Jing; Chen, Tianfeng^*; Gao, Song; Zhang, Jun-Long^*

来源：Chemistry - An Asian Journal, 2022, 17(10): e202200181.

DOI：10.1002/asia.202200181

• Phototheranostics
• Metalloporphyrinoid
• Photodynamic therapy
• MRI
• Lanthanide chemical biology

Molecular phototheranostics as an emerging field of modern precision medicine has recently attracted increasing research attention owing to non-invasiveness, high precision, and controllable nature of light. In this work, we reported promising gadolinium (Gd3+) porphyrinoids as phototheranostic agents for magnetic resonance imaging (MRI) and photodynamic therapy (PDT). The synthesized Gd-1-4-Glu featured with meso-glycosylation and beta-lactonization to endow good biocompatibility and improved photophysical properties. In particular, beta-lactonization of glycosylated Gd3+ porphyrinoids substantially red-shifted Q band absorption to near-infrared (NIR) region and boosted generation of reactive oxygen species including O-1(2), and some radical species that engaged in both type II and type I PDT pathways. In addition, the number and regioisomerism of beta-oxazolone moieties was observed to play an essential role in improving longitude relaxivity (r(1)) of Gd-1-4-Glu of up to 4.3 +/- 0.2 mM(-1)s(-1) by affecting environmental water exchange. Taking Gd-4-Glu as a promising complex, we further achieved real-time T-1-weighted MRI and PDT on HeLa tumour mice in vivo, revealing the appealing potential of Gd3+ porphyrinoids in phototheranostics.

• 单位
  北京大学; 中国科学院研究生院