Injectable Intrinsic Photothermal Hydrogel Bioadhesive with On-Demand Removability for Wound Closure and MRSA-Infected Wound Healing

作者：Kang, Xinchang; Guan, Pengfei; Xiao, Cairong; Liu, Can; Guan, Youjun; Lin, Yeying; Tian, Yu; Ren, Kunyu; Huang, Yanting; Fu, Rumin; Ning, Chengyun; Fan, Lei^*; Tan, Guoxin^*; Zhou, Lei^*

来源：Advanced Healthcare Materials, 2023, 12(13).

DOI：10.1002/adhm.202203306

• antibacterials
• dynamic cross-linking
• injectable hydrogel adhesives
• intrinsic photothermal properties
• sealants

Photothermal hydrogel adhesives have yielded promising results for wound closure and infected wound treatment in recent years. However, photothermal hydrogel bioadhesives with on-demand removability without additional nanomaterials-based photothermal agents have rarely been reported in the literature. In this work, an injectable intrinsic photothermal hydrogel bioadhesive with an on-demand removal trait is developed through dynamic cross-linking of gelatin (Gel), tannic acid (TA) quinone, and borax for closing skin incisions and accelerating methicillin-resistant Staphylococcus aureus (MRSA) infected wound healing. The TA quinone containing polyphenol and quinone groups with multifunctional adhesiveness and intrinsic photothermal performance confer the hydrogel adhesive with near-infrared (NIR) responsive antibacterial activity. The cross-linking of pH-sensitive boronic ester (polyphenol-B) and Schiff base bonds endow the hydrogel with great self-healing capacity and on-demand removability. Moreover, the hydrogel possesses good biocompatibility, injectability, and hemostasis. The in vivo experiment in a rat cutaneous incision model and full-thickness MRSA-infected wound model indicate that the smart hydrogel can close wounds efficiently and treat infected ones, demonstrating its superiority in noninvasive treatment of cutaneous incisions and enhancing infected full-thickness wound healing.

• 单位
  浙江大学; 广东工业大学; 广州医学院; 南方医科大学