Case report: Nocardia gipuzkoensis infection in an immunocompetent patient diagnosed by metagenomic next-generation sequencing and whole genome sequencing

作者：Liu, Chengxin; Yang, Juhua; Huang, Huiting; Zhan, Shaofeng^*; Xia, Xintian^*

来源：Frontiers in Immunology, 2022, 13: 1053914.

DOI：10.3389/fimmu.2022.1053914

• nocardiosis
• antibiotic susceptibility
• pathogen identification
• metagenomic next-generation sequencing
• whole genome sequencing
• case report

The infection of Nocardia gipuzkoensis is a relatively uncommon form of pulmonary nocardiosis seen in clinical patients. In general, nocardiosis tends to occur in patients with immune deficiency. Here, we report a 23-year-old female who was admitted to the hospital due to cough and sputum production over 10 years, diagnosed with bronchiectasis. The N. gipuzkoensis infection was identified by metagenomic next-generation sequencing and whole genome sequencing. Imipenem/cilastatin and compound sulfamethoxazole tablets were used to control the infection and the pulmonary inflammation subsided gradually.

• 单位
  1; 广州中医药大学