Bimetal Biomimetic Engineering UtilizingMetal-Organic Frameworks for SuperoxideDismutase Mimic

作者：Wu, Tong; Huang, Siming^*; Yang, Huangsheng; Ye, Niru; Tong, Linjing; Chen, Guosheng^*; Zhou, Quan^*; Ouyang, Gangfeng

来源：ACS Materials Letters, 2022, 4(4): 751-757.

DOI：10.1021/acsmaterialslett.2c00075

• DISMUTASE
• COPPER
• NANOPLATFORM
• NANOZYMES

In the past decade, scientists sought to engineernanomaterials with natural enzymes-like biological function,and searched for newfangled applications. Herein, we show thefirst example of utilizing a bimetal metal-organic framework(MOF-818) platform for mimicking of Cu/Zn-superoxidedismutase (Cu/Zn-SOD), an important antioxidant enzymethat specifically scavenges superoxide anions. Experimental dataand theoretical calculations reveal that the high Cu/Zn-SOD-like activity of MOF-818 results from the bimetal synergisticcatalysis, which is analogous to natural Cu/Zn-SOD. Such a bimetal biomimetic process allows for MOF-818 with much higherSOD-like activity, compared to the reported monometallic MOFs mimics. Moreover, the SOD-like MOF-818 displaysexcellent stability against heating, organic solvents, and denaturant treatments, which should inactivate natural enzymes. Basedon the catalytic mechanism, we also construct a MOF-818-based colorimetric sensing platform for phosphorylated peptidesand proteins detection. This work provides a new insight for biomimetic engineering, and may expedite the scale-upapplications of SOD-like nanozymes in variousfields.

• 单位
  南方医科大学; 5; 中山大学; 广州医学院