DNA methylation as a genomic marker of exposure to chemical and environmental agents.

Authors：Meehan Richard R^*; Thomson John P; Lentini Antonio; Nestor Colm E^*; Pennings Sari^*

Source：Current Opinion in Chemical Biology, 2018, 45: 48-56.

DOI：10.1016/j.cbpa.2018.02.006

Recent progress in interpreting comprehensive genetic and epigenetic profiles for human cellular states has contributed new insights into the developmental origins of disease, elucidated novel signalling pathways and enhanced drug discovery programs. A similar comprehensive approach to decoding the epigenetic readouts from chemical challenges in vivo would yield new paradigms for monitoring and assessing environmental exposure in model systems and humans.

• Institution
  Linkoping University