Investigation of antidiabetic effect of a new dicarboxylic acid coordination polymer with Zn(II)

作者：Yuan, Kangrui; Wang, Dongming; Ye, Xiaomei; Li, Qing; Wu, Dudu; Huang, Chaobo; Yu, Zhiqiang; Chen, Zhi^*; Lu, Chengyu

来源：Journal of Solid State Chemistry, 2021, 303: 122477.

DOI：10.1016/j.jssc.2021.122477

• Zinc-based coordination polymer
• Synthesis
• HepG(2) cells
• Insulin resistance
• Glucose consumption

In this paper, a zinc(II)-based coordination polymer, Zn-2 [(C6H8(COOH)(2)](2) (1) [(C6H8(COOH)(2) = 1,2-cyclopentanedicarboxylic acid, CPDA)], was successfully synthesized by solvothermal method. Thereafter, 1 was characterized by single crystal and powder X-ray diffraction, elemental analysis, thermogravimetric analysis and infrared spectrum techniques. In the hypoglycemic experiment, the results showed that 1 could effectively increase the glucose uptake in insulin resistance (IR)-type HepG2 cells. Besides, 1 displayed favorable antidiabetic activity in contrast to the Zinc nitrate and the CPDA ligand. The mechanism of 1 to alleviate insulin resistance might be related to the reduction of the intracellular reactive oxygen species (ROS) level and the regulation of the ROS/JNK/AKT signaling pathway.

• 单位
  南方医科大学; 广东医学院; 南京林业大学