Modeling the mechanical properties of DNA nanostructures

作者：Arbona Jean Michel^*; Aimé Jean Pierre; Elezgaray Juan

来源：Physical Review E - Statistical, Nonlinear, and Soft Matter Physics, 2012, 86(5).

DOI：10.1103/PhysRevE.86.051912

• Coarse-grained description
• DNA nanostructures
• Dna origamis
• Double-stranded DNA (ds-DNA)
• Elastic properties
• Electrostatic repulsion

We discuss generalizations of a previously published coarse-grained description of double stranded DNA (dsDNA). The model is defined at the base-pair level and includes the electrostatic repulsion between neighbor helices. We show that the model reproduces mechanical and elastic properties of several DNA nanostructures (DNA origamis). We also show that electrostatic interactions are necessary to reproduce atomic force microscopy measurements on planar DNA origamis.

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