Charge-Transfer Resonance and Electromagnetic Enhancement Synergistically Enabling MXenes with Excellent SERS Sensitivity for SARS-CoV-2 S Protein Detection

作者：Peng, Yusi; Lin, Chenglong; Long, Li; Masaki, Tanemura; Tang, Mao; Yang, Lili; Liu, Jianjun; Huang, Zhengren; Li, Zhiyuan; Luo, Xiaoying; Lombardi, John R.; Yang, Yong^*

来源：Nano-Micro Letters, 2021, 13(1): 52.

DOI：10.1007/s40820-020-00565-4

• Nb2C and Ta2C MXenes
• SERS sensitivity
• PICT resonance
• SARS-CoV-2 S protein

HighlightsNb2C and Ta2C MXenes exhibit remarkable SERS performance with the enhancement factors of 3.0x106 and 1.4x106, which is synergistically enabled by the PICT resonance enhancement and electromagnetic enhancement.The excellent SERS sensitivity endows Ta2C MXene with the capability to sensitively detect and accurately identify the SARS-CoV-2 spike protein, which is beneficial to achieve real-time monitoring and early warning of novel coronavirus. AbstractThe outbreak of coronavirus disease 2019 has seriously threatened human health. Rapidly and sensitively detecting SARS-CoV-2 viruses can help control the spread of viruses. However, it is an arduous challenge to apply semiconductor-based substrates for virus SERS detection due to their poor sensitivity. Therefore, it is worthwhile to search novel semiconductor-based substrates with excellent SERS sensitivity. Herein we report, for the first time, Nb2C and Ta2C MXenes exhibit a remarkable SERS enhancement, which is synergistically enabled by the charge transfer resonance enhancement and electromagnetic enhancement. Their SERS sensitivity is optimized to 3.0x10(6) and 1.4x10(6) under the optimal resonance excitation wavelength of 532 nm. Additionally, remarkable SERS sensitivity endows Ta2C MXenes with capability to sensitively detect and accurately identify the SARS-CoV-2 spike protein. Moreover, its detection limit is as low as 5x10(-9) M, which is beneficial to achieve real-time monitoring and early warning of novel coronavirus. This research not only provides helpful theoretical guidance for exploring other novel SERS-active semiconductor-based materials but also provides a potential candidate for the practical applications of SERS technology.

• 单位
  中国科学院研究生院; y; 上海交通大学