Ruthenium-Catalyzed Regioselective Hydrohalogenation of Alkynes Mediated by Trimethylsilyl Triflate

作者：Bai, Yuye; Lin, Zhenyuan; Ye, Zhenying; Dong, Dian; Wang, Jing; Chen, Lu^*; Xie, Feng; Li, Yibiao; Dixneuf, Pierre H.; Zhang, Min^*

来源：Organic Letters, 2022, 24(43): 7988-7992.

DOI：10.1021/acs.orglett.2c03158

• CROSS-COUPLING REACTIONS
• STEREOSELECTIVE-SYNTHESIS
• PALLADIUM
• HYDROCHLORINATION
• CHLORIDES
• ACCESS
• HYDROIODINATION
• ARYL

Here we describe a ruthenium-catalyzed regioselective hydrohaloge-nation reaction of alkynes under mild conditions. Commercially simple halogen sources such as KI, ZnBr2, and ZnCl2 were employed to achieve this transformation. Alkynes derived from bioactive molecules such as L-(-)-borneol, L-menthol, and estrone were also suitable for the transformation, demonstrating the potential synthetic value of this new reaction in organic synthesis.