MYH9: A key protein involved in tumor progression and virus-related diseases

作者：Liu, Qing; Cheng, Chao; Huang, Jiyu; Yan, Weiwei; Wen, Yinhao; Liu, Zhen^*; Zhou, Beixian^*; Guo, Suiqun^*; Fang, Weiyi^*

来源：Biomedicine and Pharmacotherapy, 2024, 171: 116118.

DOI：10.1016/j.biopha.2023.116118

• Myosin heavy chain 9
• Non-muscle myosin IIA
• Tumor
• Virus

The myosin heavy chain 9 (MYH9) gene encodes the heavy chain of non-muscle myosin IIA (NMIIA), which belongs to the myosin II subfamily of actin-based molecular motors. Previous studies have demonstrated that abnormal expression and mutations of MYH9 were correlated with MYH9-related diseases and tumors. Furthermore, earlier investigations identified MYH9 as a tumor suppressor. However, subsequent research revealed that MYH9 promoted tumorigenesis, progression and chemoradiotherapy resistance. Note-worthily, MYH9 has also been linked to viral infections, like severe acute respiratory syndrome coronavirus 2 (SARSCoV-2), Epstein-Barr virus, and hepatitis B virus, as a receptor or co-receptor. In addition, MYH9 promotes the development of hepatocellular carcinoma by interacting with the hepatitis B virus-encoding X protein. Finally, various findings highlighted the role of MYH9 in the development of these illnesses, especially in tumors. This review summarizes the involvement of the MYH9-regulated signaling network in tumors and virus-related diseases and presents possible drug interventions on MYH9, providing insights for the use of MYH9 as a therapeutic target for tumors and virus-mediated diseases.

• 单位
  广州医学院; 南方医科大学