Rising interest in the accurate and controllable anticancer strategy: Based on photon-evoked pyroptosis engineering perspective

作者：Zhang, Xiangqian; Zhang, Tuotuo; Tuo, Wei; Liu, Yanping; Umar, Talha; Chen, Yu; Wu, Zilin; Zhou, Qingqing; Li, Xiangyang^*; Deng, Ganzhen^*; Sun, Yao^*

来源：Coordination Chemistry Reviews, 2024, 501: 215588.

DOI：10.1016/j.ccr.2023.215588

• Photon-evoked pyroptosis
• Precise spatiotemporal control
• Photon-evoked strategies
• Pyroptosis pathway

Pyroptosis has garnered significant interest due to its involvement in cancer progression and potential to trigger inflammation and host immune responses. While many efforts have been made to induce pyroptosis using chemotherapeutic agents, these approaches often result in off-target effects, drug resistance, and unwanted systemic toxicity. Furthermore, the non-specific activation of pyroptosis could lead to pro-inflammatory death, creating a microenvironment that potentially heightens the chances of cancer proliferation and metastasis. To solve these limitations, photon-evoking pyroptosis engineering has emerged as a promising approach due to its precise spatiotemporal control, non-invasiveness, and reduced side effects. In this context, this work provides an overview of recent advancements in the molecular mechanisms of pyroptosis, and explore various effective strategies associated with different mode of photon-evoked pyroptosis based on the pyroptosis pathway. Thereafter, we put forth our perspectives on the challenges and prospects of utilizing photon-evoked pyroptosis in anticancer therapy.

• 单位
  华中农业大学; 贵州大学; 武汉大学; y