A Practical Synthesis of Near-Infrared Benzannulated Xanthenoid Dyes

Authors：Li, Jin; Wei, Ruwei; Zhang, Xiaodong; Luo, Xiao; Qian, Xuhong; Yang, Youjun^*

Source：Synlett, 2024, 35(01): 101-108.

DOI：10.1055/s-0042-1752719

• Key words fluorescence
• near-infrared
• benzoxanthene
• stability
• synthesis

Near-infrared dyes are sought after for their potential in biomedical applications. Benzoxanthene dyes with a non-oxygen bridging atom are expected to exhibit longer absorption and emission wavelengths than their oxygen-containing counterparts, yet their synthesis remains unaddressed. Herein, we report the first syntheses of non -oxygen-bridged benzoxanthenes starting from a 7-bromo-2-aminonaphthalene derivative, and discuss their photophysical properties as well as their potential for in vivo imaging.

• Institution
  华东理工大学