Koninginins X-Z, Three New Polyketides from Trichoderma koningiopsis SC-5

作者：Peng, Weiwei; Tan, Jianbing; Sang, Zihuan; Huang, Yuantao; Xu, Li; Zheng, Yuting; Qin, Siyu; Tan, Haibo^*; Zou, Zhenxing^*

来源：MOLECULES, 2023, 28(23): 7848.

DOI：10.3390/molecules28237848

• Trichoderma koningiopsis
• endophytic fungi
• secondary metabolites
• polyketide
• antifungal activity

Koninginins X-Z (1-3), three novel polyketides, were isolated from the solid fermentation of the endophytic fungus Trichoderma koningiopsis SC-5. Their structures, including the absolute configurations, were comprehensively characterized by a combination of NMR spectroscopic methods, HRESIMS, C-13 NMR, DFT GIAO C-13 NMR, and electronic circular dichroism calculations as well as single crystal X-ray diffraction. In addition, all the compounds were evaluated for antifungal activity against Candida albicans.

• 单位
  中国科学院