Therapeutic potential of adipose tissue derivatives in skin photoaging

摘要

Photoaging, the primary cause of exogenous skin aging and predominantly caused by ultraviolet radiation, is an essential type of skin aging characterized by chronic skin inflammation. Recent studies have shown that oxidative stress, inflammation, skin barrier homeostasis, collagen denaturation and pigmentation are themain contributors to it. As a composite tissue rich inmatrix and vascular components, adipose tissue derivatives have been recently gaining attention as potential therapeutic agents for various human diseases with fat-processing technology upgrades. This review analyzes both 'minimally treated' and 'nonminimally treated' fat derivatives to give an overview of the preclinical and clinical relevance of adipose tissue derivatives for antiphotoaging application, highlighting their good clinical prospects as well as discussing their safety and potential risks. @@@ Tweetable abstract: This review analyzes both 'minimally treated' and 'nonminimally treated' fat derivatives to provide an overview of the preclinical and clinical relevance of adipose tissue derivatives for photoaging applications. @@@ [GRAPHICS]

关键词