BRCC36 promotes intestinal mucosal barrier injury caused by BMP2 after ischemia reperfusion via inhibiting PPAR gamma signaling

作者：Zhang, Jin-Ming; Wang, Kun-Nan; Zhang, Yun; Zhang, Jun-Ze; Yuan, Xin-Pu; Zou, Gui-Jun; Cao, Zhen^*; Zhang, Chao-Jun^*

来源：Bioscience, Biotechnology and Biochemistry, 2022, 86(3): 331-339.

DOI：10.1093/bbb/zbab210

• Ischemia reperfusion
• intestinal barrier injury
• BRCC36
• PPAR gamma

As one of the most common pathological changes in trauma and surgery practice, intestinal ischemia-reperfusion (I/R) injury is regarded as a major precipitating factor in the occurrence and development of fatal diseases. BRCA1-BRCA2-containing complex subunit 36 (BRCC36), a deubiquitinase, has been proved important in a variety of pathophysiological processes such as DNA repair, cell cycle regulation, tumorigenesis, and inflammatory response. However, the effect of BRCC36 on intestinal mucosal barrier injury after I/R has not been fully elucidated. Our research found that BRCC36 aggravated intestinal mucosal barrier injury caused by bone morphogenetic protein 2 after I/R by downregulating peroxisome proliferator-activated receptor-gamma (PPAR gamma) signaling. These results suggested that BRCC36/PPAR gamma axis might serve as a potential therapeutic target for preventing intestinal mucosal barrier injury after I/R.

• 单位
  安徽医科大学; 南方医科大学; 5; 1