Supramolecular catalytic nanomedicines based on coordination self-assembly of amino acids for cascade-activated and -amplified synergetic cancer therapy

作者：Song, Enhui; Wu, Qiong; Gao, Ren; Lan, Xiaopeng; Zhang, Yanhui; Geng, Hao; Liu, Chunlei; Xu, Feijie^*; Li, Yongxin^*; Liu, Chunzhao^*

来源：Journal of Materials Chemistry B, 2022, 10(47): 9838-9847.

DOI：10.1039/d2tb02326a

• DEGRADATION
• LIGHT

Simple biomolecule-based supramolecular nanomedicines hold great promise in cancer therapy, but their clinical translation is greatly hindered by low tumor-specificity and unsatisfactory antitumor performance. Herein, we developed an amino acid basedsupramolecular nanomedicine that could be co-activated by multiple stimuli in tumor tissue to trigger cascade catalytic reactions in situ for synergetic therapy. The supramolecular nanomedicine was developed based on a combination of coordination and hydrophobic noncovalent interactions among amphiphilic amino acids, glucose oxidase (GOx), copper ions, as well as doxorubicin (DOX)-camptothecin (CPT) prodrugs. The cascade reactions including the catalytic oxidation of glucose to generate H2O2, GSH reducing Cu2+ to Cu+, a Fenton-like reaction between H2O2 and Cu+ to produce hydroxyl radicals (OH), and OH-triggered rapid release of dual parent drugs were specifically activated in tumor cells. With these cascade reactions, the catalytic-chemo synergetic therapy was realized for high-efficiency tumor suppression.

• 单位
  青岛大学