Coupling of Geant4-DNA physics models into the GATE Monte Carlo platform: Evaluation of radiation-induced damage for clinical and preclinical radiation therapy beams

作者：Pham, Q.T.; Anne, A.; Bony, M.; Delage, E.; Donnarieix, D.; Dufaure, A.; Gautier, M.; Lee, S.B.; Micheau, P.; Montarou, G.; Perrot, Y.; Shin, J.I.; Incerti, S.; Maigne, L.^*

来源：Nuclear Instruments and Methods in Physics Research, Section B: Beam Interactions with Materials and Atoms , 2015, 353: 46-55.

DOI：10.1016/j.nimb.2015.04.024

• Clinical proton beams
• Constant improvement
• Energy depositions
• GATE
• Geant4 dnas
• Multi-scale simulation
• Nanodosimetry
• Radiation induced damage

The GATE Monte Carlo simulation platform based on the Geant4 toolkit is in constant improvement for dosimetric calculations. In this paper, we present the integration of Geant4-DNA processes into the GATE 7.0 platform in the objective to perform multi-scale simulations (from macroscopic to nanometer scale). We simulated three types of clinical and preclinical beams: a 6 MeV electron clinical beam, a X-ray irradiator beam and a clinical proton beam for which we validated depth dose distributions against measurements in water. Frequencies of energy depositions and DNA damage were evaluated using a specific algorithm in charge of allocating energy depositions to atoms constituting DNA molecules represented by their PDB (Protein Data Bank) description.

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