Aptamer-Gold Nanocage Composite for Photoactivated Immunotherapy

作者：Song, Wen; Hu, Jing-Jing; Song, Shu-Jun; Xu, Yi; Yang, Hang; Yang, Fan; Zhou, Ying^*; Yu, Tao^*; Qiu, Wen-Xiu^*

来源：ACS applied materials & interfaces, 2022, 14(38): 42931-42939.

DOI：10.1021/acsami.2c11089

• immune checkpoint blockade
• aptamer
• gold nanocage
• photothermal therapy
• light targeting

Immune checkpoint blockade (ICB) has been hailed as the hope for conquering cancer as ICB could produce a significant and durable response to tumor cells. However, the high cost and severe side effects of ICB drugs limited their application for further anticancer therapy. Here, we developed a photoactivated immunotherapy nanoplatform (Apt@AuNC). This nanoplatform could target tumor tissues via enhanced penetration retention (EPR) effect and the aptamer (Apt) could be released from Apt@AuNC in tumor sites via illumination. The immune system in the tumor area was then activated after the combination of Apt and PD-1 protein. The heat generated from AuNC was able to continue killing tumor cells. This nanoplatform could not only achieve the precise immunotherapy but also significantly facilitate the anticancer efficacy.

• 单位
  上海交通大学; y