Synthesis of acridinones via palladium-catalyzed reductive annulation of 2-nitrobenzaldehydes and resorcinols

Authors：Xie, Rong; Mao, Wenhui; Jia, Huanhuan; Lu, Guangpeng; Sun, Jialu; Jiang, Huanfeng; Zhao, He^*; Zhang, Min^*

Source：Organic Chemistry Frontiers, 2022, 9(4): 953-958.

DOI：10.1039/d1qo01693h

• SOLVENT-FREE CONDITIONS
• N BOND FORMATION
• ACRIDONE ALKALOIDS
• C-C
• EFFICIENT
• ALKYLATION
• DERIVATIVES
• ACID
• FUNCTIONALIZATION
• GLYFOLINE

The catalytic conversion of biomass-derived feedstocks into functional molecules is of significance to synthetic organic chemistry. Herein, through a palladium-catalyzed reductive annulation reaction of resorcinols and 2-nitrobenzaldehydes, we present a new approach for the direct synthesis of acridinone derivatives, featuring operational simplicity, good substrate compatibility, and readily available feedstocks.