The relationship between serum 25-hydroxyvitamin-D level and sweat function in patients with type 2 diabetes mellitus

作者：Chen, T.; Zhang, Z.; Lei, H.; Fen, Z.; Yuan, Y.; Jin, X.; Zhou, H.; Liu, J.; Wang, W.; Guo, Q.; Li, L.^*; Shao, J.^*

来源：Journal of Endocrinological Investigation, 2022, 45(2): 361-368.

DOI：10.1007/s40618-021-01651-z

• Serum 25-hydroxyvitamin-D
• Sweat function
• Type 2 diabetes mellitus
• Diabetic peripheral neuropathy

Aims The objective of this study is to explore the relationship between serum 25-hydroxyvitamin-D(25-(OH)(2)D-3) level and sweat function in patients with type 2 diabetes mellitus (T2DM). Methods A cross-sectional study of 1021 patients with T2DM who underwent 25-(OH)(2)D-3 level detections and sweat function tests was carried out. These individuals were divided into deficient groups (n = 154 cases), insufficient groups (n = 593 cases) and sufficient groups (n = 274 cases). Spearman correlation analysis and multivariate stepwise linear regression analysis were implemented to determine the association of 25-(OH)2D3 level and sweat function. Results The total presence of sweating dysfunction was 38.59%. Patients with a lower level of serum 25-(OH)(2)D-3 had more severe sweat secretion impairment (P < 0.05). As the decrease of serum 25-(OH)(2)D-3 level, the presence of sweating dysfunction increased (P < 0.05). 25-(OH)(2)D-3 level was positively correlated with sweat function parameters, age and duration of T2DM were negatively correlated with sweat function parameter (P < 0.05). Multivariate stepwise linear regression analysis explored a significant association between serum 25-(OH)(2)D-3 level with sweat P < 0.05). Conclusions Serum 25-(OH)(2)D-3 level was positively correlated with sweat function in patients with T2DM.

• 单位
  中山大学; 南京大学; 南方医科大学