Nanorobot-Mediated Synchronized Neuron Activation

作者：Chen, Bin; Tan, Haixin; Ding, Miaomiao; Liu, Lu; Wang, Shuanghu; Peng, Xiuyun; Tian, Hao; Jiang, Jiamiao; Gao, Junbin; Huang, Weichang; Li, Huaan; Ye, Yicheng; Wang, Fei; Wilson, Daniela A.; Tu, Yingfeng^*; Peng, Fei^*

来源：ACS Nano, 2023, 17(14): 13826-13839.

DOI：10.1021/acsnano.3c03575

• nanorobot
• collective behaviors
• oscillation
• neuronal resonance
• light actuation

Interactions between active materials lead to collectivebehaviorand even intelligence beyond the capability of individuals. Such behaviorsare prevalent in nature and can be observed in animal colonies, providingthese species with diverse capacities for communication and cooperation.In artificial systems, however, collective intelligence systems interactingwith biological entities remains unexplored. Herein, we describe black(B)-TiO2@N/Au nanorobots interacting through photocatalyticpure water splitting-induced electrophoresis that exhibit periodicswarming oscillations under programmed near-infrared light. The periodicchemical-electric field generated by the oscillating B-TiO2@N/Au nanorobot swarm leads to local neuron activation in vitro. The field oscillations and neurotransmission fromsynchronized neurons further trigger the resonance oscillation ofneuron populations without synaptic contact (about 2 mm spacing),in different ways from normal neuron oscillation requiring directcontact. We envision that the oscillating nanorobot swarm platformswill shed light on contactless communication of neurons and offertools to explore interactions between neurons.

• 单位
  南方医科大学; 6; 中山大学