Cu(II) Metal-Organic Framework Encapsulated in Carbon Paste Electrode for High-Performance Non-Enzymatic Glucose Sensing

作者：Wu, Lan; Lu, Zhi-Wei; Ma, Ying; Zhang, Jun-Jun; Mo, Guang-Quan; Du, Hai-Jun^*; Ye, Jian-Shan^*

来源：CHINESE JOURNAL OF ANALYTICAL CHEMISTRY, 2020, 48(3): E20038-E20046.

DOI：10.1016/S1872-2040(20)60006-8

• Copper metal-organic framework
• Carbon paste electrode
• Non-enzymatic
• Glucose
• Chronoamperometry

A novel electrochemical non-enzymatic sensing system was fabricated based on carbon paste electrode (CPE) encapsulating copper metal-organic frameworks (Cu-MOF/CPE) for determination of glucose by chronoamperometry in alkaline media. The as-synthesized Cu-MOF exhibited high surface area and porous structures, and the presence of carbon pastes greatly improved the conductivity of the sensing electrode. This synergic effect led to the good catalytic activity of the resulting electrode toward glucose. Under the optimized experimental conditions, the oxidation peak currents were linearly dependent on glucose concentrations in a wide range of 5-3910 mu mol/L and 3910-10950 mu mol/L with a limit of detection (LOD) of 0.11 mu mol/L and a short response time of 0.5 s. Moreover, the developed sensor showed long-time stability, excellent selectivity as well as high resistance towards interferences. This sensor was also applied to determination of glucose in serum samples with a satisfactory result, confirming its promising applications.

• 单位
  广州医学院; 广东药学院