An Active Compound From Pseudomonas aeruginosa B27

摘要

A compound was isolated from the fermented broth of Pseudomonas aeruginosa. The compound was determined as acridine-4-carboxylic acid based on nuclear magnetic resonance, mass spectrometry (MS), and single-crystal x-ray diffraction analysis. Acridine-4-carboxylic acid showed significant antibacterial activities against Staphylococcus aureus, Bacillus cereus, Bacillus subtilis, Bacillus megaterium, and Shinella sp. Moreover, the compound showed certain antitumor activities against HCT116, ST486, HCC1806, and A549 with IC(50)values of 38.38, 6.59, 20.69, and 82.81 mu g/mL, respectively. In the test of nematicidal activity, acridine-4-carboxylic acid showed certain nematicidal activity against Caenorhabditis elegans and Meloidogyne incognita. In addition, the compound also exhibited 1,1-diphenyl-2-picrylhydrazyl free radical scavenging activity. Therefore, this compound may be used as a potential antibacterial, antitumor, nematicidal, and antioxidative agent.

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