Theoretical insight into phosphoric acid-catalyzed asymmetric conjugate addition of indolizines to a,β-unsaturated ketones

作者：Haohua Chen; Lei Zhu; Kangbao Zhong; Xiaoyu Yue; Ling-Bo Qu; Ruopeng Bai; Yu Lan

来源：CHINESE CHEMICAL LETTERS, 2018, 29(08): 1237-1241.

Phosphoric acid catalysis is a powerful tool for the construction of new CààC bonds because of its unique LUMO-lowering activity. Theoretical calculations were employed to investigate phosphoric acidcatalyzed asymmetric conjugate addition of indolizines to a,b-unsaturated ketones. The calculation results showed that this transformation proceeds via a reaction pathway involving nucleophilic addition,deprotonation–aromatization, and tautomerization. The computational results showed that deprotonation–aromatization is the rate-determining step and the enantioselectivity-determining step.The S-configured product was preferentially generated via a pathway starting from the s-cis conjugated ketone, whereas the s-trans isomer led to a side product with the R configuration. Non-covalent interaction analysis showed that the enantioselectivity is mainly caused by bond-rotation strain in the transition states of the deprotonation–aromatization step.

• 单位
  郑州大学