MEX3C-Mediated Decay of SOCS3 mRNA Promotes JAK2/STAT3 Signaling to Facilitate Metastasis in Hepatocellular Carcinoma

作者：Xiao, Yunyun; Li, Yue; Shi, Dongni; Wang, Xiaoqing; Dai, Shuqin; Yang, Muwen; Kong, Lingzhi; Chen, Boyu; Huang, Xinjian; Lin, Chuyong; Liao, Wenting; Xu, Benke; Chen, Xin; Wang, Lishuai; Chen, Xiangfu; Ouyang, Ying; Liu, Guozhen^*; Li, Heping^*; Song, Libing^*

来源：Cancer Research, 2022, 82(22): 4191-4205.

DOI：10.1158/0008-5472.CAN-22-1203

• BINDING PROTEINS
• EXPRESSION
• STAT3
• PLAYERS

with MEX3C-specific antisense oligonucleotide significantly inhib-ited JAK2/STAT3 pathway activation, suppressing HCC migration in vitro and metastasis in vivo. These findings highlight a novel mRNA decay-mediated mechanism for the disruption of SOCS3-driven negative regulation of JAK2/STAT3 signaling, suggesting MEX3C may be a potential prognostic biomarker and promising therapeutic target in HCC.Significance: This study reveals that RNA-binding protein MEX3C induces SOCS3 mRNA decay to promote JAK2/STAT3 activation and tumor metastasis in hepatocellular carcinoma, iden-tifying MEX3C targeting as a potential approach for treating metastatic disease.

• 单位
  1; 广州医学院; 南方医科大学; 中山大学