Optimization of jujube peel pigment multivesicular liposome formulation and evaluation of the protective effect on UVB-induced photodamage

作者：Liu, Zhiming; Zheng, Ying; Yue, Bowen; Luo, Yali; Cao, Zhaoxin; Su, Jingyi; Wang, Xinyu; Zhang, Yan; Zhang, Yifei; Wang, Bingxue; Cheng, Xiaoliang^*; Zhou, Zhiyong^*; Ge, Xuemei^*

来源：European Journal of Lipid Science and Technology, 2023, 125(9).

DOI：10.1002/ejlt.202300009

• antioxidant
• controlled release
• jujube peel pigments
• multivesicular liposomes
• photoaging

Jujube peel pigment (JP), an ideal natural water-soluble pigment extracted from jujube peel, mainly consists of flavonoids and possesses a wide range of physiological activities. In this study, JP-loaded multivesicular liposomes (JP-MVL) were prepared using the double emulsification method. JP-MVL was characterized, and its encapsulation efficiency was determined using the UV-Vis method. Furthermore, the release behavior and antioxidant capacity of JP-MVL were evaluated in vitro. The results displayed in the structure of JP-MVL were spherical with internal vesicles; the average particle size of JP-MVL was 5.63 & mu;m, and the zeta potential was -69.50 mV. Analysis of the release results indicated that the best-fitting models in PBS (Phosphate buffered saline pH 7.4) and 0.9% NaCl were the Higuchi and first-order kinetic models, respectively. The cytotoxicity of JP-MVL at the appropriate concentrations was negligible and had a good protective effect against UVB-induced photodamage.

• 单位
  1; 西安交通大学; 南京林业大学