The rapidly evolving research on vitamin D among HIV-infected populations

作者：Overton E T^*; Yin M T

来源：Current Infectious Disease Reports, 2011, 13(1): 83-93.

DOI：10.1007/s11908-010-0144-x

• AIDS
• Bone health
• HIV
• Vitamin D

With ongoing improvement in antiretroviral therapy, mortality among HIV-infected persons has dramatically decreased. For HIV-infected persons who remain engaged in care on suppressive therapy, life expectancy approaches that of the general population. Additionally, we have seen increases in comorbidities traditionally associated with aging: diabetes, hypertension, dyslipidemia, ischemic heart disease, and osteoporosis. Vitamin D deficiency has also been identified as a highly prevalent entity among HIV-infected populations. The association of vitamin D deficiency with several of these comorbidities and its impact on immune function provide the impetus for well-designed studies to evaluate the impact of vitamin D supplementation on HIV disease and antiretroviral therapy. This review summarizes the role of vitamin D in several disease states that are prevalent among HIV populations, with a specific focus on bone health and the interactions with antiretroviral medications.

• 单位
  Washington University ,School of Medicine; new; United States; Columbia University Medical Center; Washington University School of Medicine