The effects of microbiota-targeted approaches in inflammatory bowel disease: probiotics, probiotic foods, and prebiotics

作者：Xia, Bing; Liu, Xiaoning; Li, Zhiqing; Ren, Jiaoyan; Liu, Xuebo^*

来源：Current Opinion in Food Science, 2023, 49: 100956.

DOI：10.1016/j.cofs.2022.100956

• INTESTINAL BARRIER FUNCTION
• GUT MICROBIOTA
• ULCERATIVE-COLITIS
• CELLS
• MILK

Inflammatory bowel disease (IBD) has emerged as a global disease with a complex pathogenesis, while perturbations in the gut microbiota have been shown to be closely related to its initiation and progression. Gut microbiota-targeted nutritional interventions have been promoted as promising approaches for managing IBD. Here, we summarize the latest understanding of gut microbiota in the context of IBD through its interactions with susceptibility genes, the intestinal barrier, host immunity, and metabolites. We also present abundant evidence on the effects of nutritional strategies that target the microbiota, including probiotics, probiotic foods, and prebiotics. Our research suggests that more clinical trials and mechanistic studies on IBD are needed to contribute to their applications as dietary supplements or functional foods.

• 单位
  西北农林科技大学