Deceased Donor Predictors for Pediatric Liver Allograft Utilization

作者：Xie, Rongxing; Huang, Shanzhou; Sun, Chengjun; Zhu, Zebin; Tang, Yunhua; Zhao, Qiang; Guo, Zhiyong; He, Xiaoshun^*; Ju, Weiqiang^*

来源：Transplantation Proceedings, 2020, 52(10): 2901-2908.

DOI：10.1016/j.transproceed.2020.05.010

• NOVO HEPATITIS-B
• ORGAN DONATION
• CYTOMEGALOVIRUS-INFECTION
• TRANSPLANT RECIPIENTS
• POSITIVE DONORS
• VIRUS-INFECTION
• DISEASE
• SURVIVAL
• DEATH
• CANDIDATES

Background. The number of pediatric deceased organ donors has recently declined, and the nonutilization of pediatric liver allografts has limited the development of liver transplantation. We determined the utilization rate of pediatric livers and identified risk factors for graft discard. @@@ Methods. We used data from the Scientific Registry of Transplant Recipients database from January 1, 2000, to December 31, 2012. The trends of pediatric liver donors and utilization rates were analyzed. Donor risk factors that impacted the graft use of pediatric livers were measured. Logistic regression modelling was performed to evaluate graft utilization and risk factors. @@@ Results. A total of 11,934 eligible pediatric liver donors were identified during this period. A total of 1191 authorized liver grafts did not recover or recovered without transplantation. Factors including pediatric donors .001), hepatitis B surface antigen positivity (OR = 4.588, 95% CI 1.021-20.625,P = .047), anti-hepatitis C virus positivity (OR = 4.691, 95% CI 1.352-16.280, P = .015), total bilirubin .001), and blood urea nitrogen 21 mg/dL (OR =1.941, 95% CI 1.546-2.436, P < .001) were significantly related to graft nonutilization. Steroids or diuretics administered prerecovery were significantly related to graft utilization (OR = 0.684, 95% CI 0.581-0.806,P < .001; OR = 0.744, 95% CI 0.634-0.874, P < .001; respectively). @@@ Conclusions. The pediatric liver allograft utilization rate and risk factors for non -utilization of grafts were determined.

• 单位
  1; 广东省人民医院; 中山大学; i