α-Glucosidase inhibitory activities of constituents from Psidium guajava leaves

摘要

Psidium guajava is a plant of the Myrtaceae with various pharmacological activity. In this study, the water extract and the isolated compounds from guava leaves were evaluated for in vitro a-glucosidase inhibition using spectrophotometric method. Ellagic acid, quercetin, quercetin-3-O-glucuronide, avicularin, isoquercitrin, and quercetin-3-galactoside showed a-glucosidase inhibitory activity, and their IC50 value were 25.0, 41.0, 53.5, 46.9, 60.0 and 72.1 mu g/ mL, respectively compared with the positive control acarbose (IC50 49.2 mu g/mL). This study could provide a theoretical basis for the application of Psidium guajava in the treatment of hyperglycemia. @@@ [GRAPHICS.]Y

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