New phenanthrene derivatives with nitric oxide inhibitory and radical-scavenging activities from Pholidota imbricata Hook.

作者：Wang Jue; Wang Tiejie; Xie Pu; Yin Guo; Li Xiaofan^*

来源：Natural Product Research, 2014, 28(4): 251-256.

DOI：10.1080/14786419.2013.847437

• phenanthrene
• nitric oxide production
• radical-scavenging activity
• Pholidota imbricata Hook

One new phenanthrene derivative phoimbrtol A (1) with seven known compounds, loddigesiinol B (2), shanciol B (3), (-)-medioresinol (4), (-)-pinoresinol (5), quercetin 3-O--l-arabinofuranoside (6), luteolin 7-O--glucoside (7) and platycaryanin D (8) have been isolated from the ethyl acetate extract of the air-dried whole plant of Pholidota imbricata Hook. Their inhibitory effects on nitric oxide (NO) production and 1,1-diphenyl-2-picrylhydrazil (DPPH) radical scavenging activity were examined. Among these compounds, 8 exhibited the most potent activity at NO production inhibitory assay and DPPH radical scavenging assay, stronger than those of the familiar antioxidative agents, quercetin and resveratrol.

• 单位
  深圳市药品检验所; shenzhen univ; 沈阳药科大学