The long-term outcomes of clinical responders to neoadjuvant chemotherapy followed by radical surgery in locally advanced cervical cancer

作者：Li, Weili; Liu, Ping; He, Fangjie; Sun, Lixin; Zhao, Hongwei; Wang, Li; Guo, Jianxin; Yang, Ying; Bin, Xiaonong; Lang, Jinghe; Chen, Chunlin^*

来源：Journal of Cancer Research and Clinical Oncology, 2023, 149(8): 4867-4876.

DOI：10.1007/s00432-022-04401-7

• Cervical cancer
• Neoadjuvant chemotherapy
• Radiotherapy
• Clinical response
• Laparotomy

Objective To compare the long-term oncological outcome of neoadjuvant chemotherapy before radical surgery (NCRS) and definitive chemoradiotherapy (DR) for stage IB2 and IIA2 cervical squamous cell carcinoma. @@@ Methods The clinical outcome of 480 patients with stage IB2 and IIA2 cervical cancer (308 clinical responders, 111 clinical non-responders, 61 unclear) who underwent NCRS (and subgroup assessments) were compared with those of 233 patients who underwent DR. @@@ Results The clinical response rate was 73.5% in the NCRS group. Multivariate COX regression analyses revealed that NCRS was not correlated with the 5-year overall survival (OS) rate (p = 0.067) or disease-free survival (DFS) rate (p = 0.249). In a subgroup of NCRS, the clinical response group was also shown to be a protective independent factor of 5 year OS rate compared to the DR group (aHR, 0.403; 95% CI, 0.209-0.777), but had no correlation with the 5 year DFS rate (p = 0.089). On the other hand, the clinical non-response group had no correlation with the 5 year OS rate (p = 0.780) or DFS rate (p = 0.669). @@@ Conclusion Clinical responders who underwent NCRS exhibited a better oncological outcome compared to those who underwent DR.

• 单位
  郑州大学; 广州医学院; 南方医科大学; 中国医学科学院北京协和医院